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This represents an exposure of about 2 and 6 times the MRHD dose of 2000 mg of the metformin component of Metaglip based on body surface area comparisons for rats and rabbits, respectively. Determination of fetal concentrations demonstrated a partial placental barrier to metformin. This has been reported more frequently with the use of cans I Get A Prescription For Kamagra Soft Online with prolonged half-lives. It is not recommended that Metaglip be used during pregnancy. However, if it is used, Metaglip should be discontinued at least 1 month before the expected delivery date. Studies in lactating rats show that metformin is excreted into milk and reaches levels comparable to those in plasma.
Similar studies have not been conducted in nursing mothers. If Metaglip is discontinued, and if diet alone is inadequate for controlling blood glucose, insulin therapy should be considered. Safety and effectiveness of Metaglip in pediatric patients have not been established.
Of the 87 patients who received Metaglip in the second-line therapy trial, 17 19. Because aging is associated with reduced renal function, Metaglip should be used with caution as age increases. Care should be taken in dose selection and should be based on careful and regular monitoring of renal function. In a double-blind 24-week clinical trial involving Metaglip as initial therapy, a total of 172 patients received Metaglip 2. The most common clinical adverse events in these treatment groups are listed in Table 4. The most common clinical adverse events in this clinical trial are listed in Table 5.
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- Similar studies have not been conducted in nursing mothers.
- This represents an exposure of about 2 and 6 times the MRHD dose of 2000 mg of the metformin component of Metaglip based on body surface area comparisons for rats and rabbits, respectively.
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